Current experiment

PQQ + Ubiquinol

An 8-12 week test for a repeatable energy, recovery, or cognition signal without worse sleep, anxiety, blood pressure, or tolerance. Personal experiment record, not medical advice, prescribing, sourcing guidance, or an instruction to copy.

Primary question: Can PQQ 20 mg plus Ubiquinol 100 mg produce a noticeable energy, recovery, or cognition signal over 8-12 weeks without creating sleep disruption, anxiety, blood-pressure drift, or tolerance issues?

Research Summary

What it is

PQQ is a quinone compound studied around mitochondrial signaling, redox biology, fatigue, sleep, and cognition. Ubiquinol is the reduced form of CoQ10, a fat-soluble compound involved in mitochondrial electron transport and ATP production.

Why it caught my attention

This is one of the cleaner supplement-side experiments for the mitochondrial lane. The claim is not acute stimulation. The question is whether mitochondrial support shows up as lower daily fatigue friction, better training tolerance, or steadier cognitive energy.

PQQ evidence

PQQ has small human studies around fatigue, sleep, and cognition, plus mechanistic work around mitochondrial signaling. That makes it interesting enough to test, but not strong enough to treat as a settled performance or longevity intervention.

CoQ10 context

CoQ10 has a larger human evidence base than PQQ, but exercise and performance effects are inconsistent unless there is a specific need, medication context, or low-status problem. I am using Ubiquinol rather than stacking Ubiquinol and standard CoQ10 so the experiment stays cleaner.

Safety boundary

This is still filed as an experiment, not a permanent routine assumption. The practical watch points are sleep quality, anxiety, blood pressure, resting heart rate, gastrointestinal tolerance, and whether the effect is clear enough to justify another daily pill.

Sources

The Experiment

Protocol

I start this experiment on June 30, 2026. The logged stack entries are PQQ 20 mg and Ubiquinol 100 mg, both from Nutricost, taken after the daily large meal.

Hypothesis

The useful result would be subtle but repeatable: better morning energy, less afternoon drag, improved training recovery, or cleaner mental output without feeling stimulated.

Primary watch signals

The signals I care about most are energy, sleep quality, sleep onset, resting heart rate, blood pressure, workout recovery, zone 2 feel, gastrointestinal tolerance, anxiety, and whether the effect is noticeable enough to justify keeping.

Decision rule

This only earns a place if the signal is clear after 8-12 weeks. If the result is vague, redundant, or only maybe helpful, it stays out of the permanent routine.