NP Thyroid + T3

How it started

I added NP Thyroid at 15 mg daily on August 24, 2026 to see whether it would produce a repeatable change in daily energy or the rate of weight loss during my cut. It is a prescribed desiccated thyroid product from TelyRx, taken alone during my usual overnight wake-up, at least four hours after the bedtime stack.

How it became a T3 experiment

My September 16 bloodwork showed free T3 at 2.1 pg/mL, below the 2.3–4.2 range, and reverse T3 at 36 ng/dL, above its 8–25 range. Earlier in 2026, my free T3 had been between 2.7 and 3.3. That changed the question from whether a small dose of NP Thyroid helps to whether I can bring free T3 back into range while I keep dieting. I increased NP Thyroid, then added T3 when that did not work.

Protocol history

Since October 7, I take NP Thyroid and T3 together at about 1 AM. The 40 mcg pill replaces the 25 mcg rather than adding to it. The T3 is from the gray market. The 40 mcg pill is a different product from the 25 mcg, so the next thyroid check also confirms how it performs. I keep NP Thyroid at 30 mg while adjusting T3, so only one thing changes at a time. Both are listed in my Daily Stack.

What I track

Free T3 is the primary marker. Total T3, free T4, and TSH come with every check, using the same dose time and a similar early-morning draw so results compare cleanly. Daily energy and the rate of fat loss remain the outcomes I care about. Resting heart rate, sleep, and blood pressure show whether the dose is well tolerated.

My decision rules

I want free T3 around 3.0 pg/mL at my usual draw timing, staying within the reference range rather than above it. I step back to the previous T3 dose if resting heart rate stays about 10 bpm above my pre-T3 level, or if I notice palpitations, worse sleep, or higher blood pressure. The next check repeats the same four tests after about a week on 40 mcg.

Adding T3: October 5 to October 19

NP Thyroid 30 mg alone on October 5; NP Thyroid 30 mg plus T3 25 mcg for 13 days by October 19.

Ranges, units, and timing

All results are from Quest Diagnostics with the same reference ranges: free T3 2.3–4.2 pg/mL, total T3 76–181 ng/dL, free T4 0.8–1.8 ng/dL, TSH 0.40–4.50 mIU/L, and reverse T3 8–25 ng/dL. L and H are the laboratory's flags.

Reverse T3 was measured three times: 16 ng/dL on January 2, 27 H on July 15, and 36 H on September 16. Total T3 was first measured in October: 40 L on October 5 and 76 on October 19.

Dose-to-draw timing matters because T3 peaks within hours of a dose. The September 16 draw was about 3 hours 40 minutes after NP Thyroid. The October 5 draw was about 6 hours after it, and the October 19 draw about 6.5 hours after both doses. I keep the October timing as the standard for future checks.

Doubling NP Thyroid did not raise T3

Between September 16 and October 5, TSH fell from 1.60 to 1.06, free T4 from 1.0 to 0.8, and free T3 from 2.1 to 1.7. At this dose, NP Thyroid mostly replaced my own thyroid output instead of adding to it: as the pill supplied more hormone, my body made less. The later October 5 draw time may account for part of the free T3 drop, but free T4 and TSH moved the same way.

NP Thyroid is mostly T4, which has to be converted into active T3. While my free T3 fell, reverse T3, an inactive form, climbed from 16 in January to 27 in July and 36 in September. My T4 was not turning into enough active T3, and more NP Thyroid would mostly add more T4.

T3 worked

T3 bypasses the conversion step. After 13 days at 25 mcg, free T3 rose 0.9 pg/mL and total T3 nearly doubled. TSH did not move, so my pituitary was not reading this as too much thyroid hormone. Free T4 dropped slightly, which is the expected direction when T3 is supplied directly.

Total T3 and Anavar

Anabolic steroids can lower thyroxine-binding globulin, the main protein that carries thyroid hormone in the blood. That lowers total hormone levels while free levels stay unchanged, which fits my total T3 sitting low relative to free T3. Both October draws were during Anavar use, which ended October 18, and testosterone and nandrolone continue. I judge the experiment by free T3.

Where it stands

Free T3 is back in range at 2.6 pg/mL, but in the lower third and below the 2.7–3.3 I had earlier in 2026. The move to 40 mcg T3 is meant to close that gap. The daily energy and fat-loss outcomes have not been assessed yet; I will add them once the free T3 level is settled.

Calorie restriction and T3

In lean, weight-stable adults who had practiced long-term calorie restriction, serum T3 averaged 73.6 ng/dL, compared with 91.0 and 94.3 ng/dL in two comparison groups, while T4, reverse T3, and TSH were similar. The NP Thyroid label also lists chronic caloric deprivation among the conditions with low T3. Total fasting lowers T3 and raises reverse T3, and both return to normal with refeeding; with an 800 kcal diet, T3 fell but reverse T3 did not rise. Fontana et al., 2006 · Vagenakis et al., 1975 · Spaulding et al., 1976.

What NP Thyroid supplies

The label lists 38 mcg T4 and 9 mcg T3 per grain (60 mg). A 15 mg tablet supplies 9.5 mcg T4 and 2.25 mcg T3; a 30 mg tablet supplies 19 mcg T4 and 4.5 mcg T3. At 30 mg, most of the dose is T4 that still has to be converted. NP Thyroid label.

Why draw timing matters

In healthy adults given a single 50 mcg dose of T3, serum T3 peaked about 2.5 hours later and declined with a half-life of roughly 22 hours. The Cytomel label describes near-complete absorption within 4 hours and a biological half-life of about 2.5 days. A draw a few hours after the dose therefore reads differently from one later in the day, which is why I keep dose and draw times consistent. Jonklaas et al., 2015 · Cytomel label.

Anabolic steroids and thyroid tests

Oxandrolone labeling notes that anabolic steroids may decrease thyroxine-binding globulin, lowering total T4 and increasing resin uptake of T3 and T4, while free thyroid hormone levels remain unchanged. T3 travels on the same protein, so total T3 is affected the same way. Oxandrin label.

Why I am not pushing higher

In obese adults during fasting, T3 at 60 mcg a day or more increased muscle breakdown. Preserving muscle is part of the point of my cut, which is one reason my target is a mid-range free T3 rather than the top of the range. Burman et al., 1979.

Sources

• Fontana et al., Journal of Clinical Endocrinology and Metabolism, 2006: long-term calorie restriction and thyroid hormones in humans.
• Vagenakis et al., Journal of Clinical Endocrinology and Metabolism, 1975: T3 and reverse T3 during total fasting and refeeding.
• Spaulding et al., Journal of Clinical Endocrinology and Metabolism, 1976: T3 and reverse T3 with fasting and hypocaloric diets.
• NP Thyroid prescribing information (DailyMed): T4 and T3 content per tablet.
• Jonklaas et al., Therapeutic Drug Monitoring, 2015: single-dose liothyronine pharmacokinetics in healthy adults.
• Cytomel prescribing information (Pfizer): liothyronine absorption and half-life.
• Oxandrin prescribing information (DailyMed): anabolic steroid effects on thyroid-binding protein and thyroid tests.
• Burman et al., Metabolism, 1979: T3 and muscle catabolism during fasting.